A structural view of ligand-dependent activation in thermoTRP channels

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A structural view of ligand-dependent activation in thermoTRP channels

Transient Receptor Potential (TRP) proteins are a large family of ion channels, grouped into seven sub-families. Although great advances have been made regarding the activation and modulation of TRP channel activity, detailed molecular mechanisms governing TRP channel gating are still needed. Sensitive to electric, chemical, mechanical, and thermal cues, TRP channels are tightly associated with...

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ژورنال

عنوان ژورنال: Frontiers in Physiology

سال: 2014

ISSN: 1664-042X

DOI: 10.3389/fphys.2014.00171